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. Author manuscript; available in PMC: 2013 Sep 21.
Published in final edited form as: Immunity. 2012 Sep 21;37(3):389–398. doi: 10.1016/j.immuni.2012.08.011

Figure 3. Innate Recognition of HIV-1 in CD4 T Cells.

Figure 3

CD4 T cells are either productively infected or nonpermissive for HIV-1 replication.

(A) In permissive CD4 T cells, HIV-1 recognition by cytosolic DNA sensor is blocked by TREX1 degradation of RT intermediate DNA products.

(B) In CD4 T cells that are abortively infected, HIV-1 triggers death by possibly inducing apoptosis and inflammasome activation (pyroptosis). These pathways of cell death are mediated by a cytosolic DNA sensor that is stimulated by accumulation of defective RT products.