Table 3.

SNPs associated with log CD34⁺ after adjustment for age and sex

Candidate gene(s)	Loci	SNP	Position, bp	Location relative to gene	MAF	A1-A2	Estimated regression coefficient (SE)*	P
OR4C12	11p11.1	rs2183383	50194788	Downstream	0.20	C-T	−0.22 (0.04)	6.67 × 10−7
ENO1, RERE	1p36	rs11121242	8828888	Intergenic	0.48	G-A	−0.19 (0.04)	8.81 × 10−7
		rs6577536	8832697	Intergenic	0.47	G-A	−0.18 (0.04)	9.78 × 10−7
		rs11121245	8838811	Downstream	0.49	C-T	−0.17 (0.04)	3.10 × 10−6
		rs11590606	8840256	Downstream	0.49	T-C	−0.17 (0.04)	3.17 × 10−6
		rs10864368	8840900	Downsteram	0.49	C-T	−0.17 (0.04)	3.18 × 10−6
DGKB	7p21	rs976760	14240178	Intronic	0.26	C-T	0.25 (0.05)	2.86 × 10−6
DSC3	18q12	rs1943535	26620710	Intergenic	−0.25	G-T	−0.25 (0.05)	4.61 × 10−6
		rs2591120	26621355	Intergenic	−0.25	A-T	−0.25 (0.05)	4.62 × 10−6
		rs2591119	26621746	Intergenic	−0.25	A-G	−0.25 (0.05)	4.65 × 10−6
		rs2591118	26621891	Intergenic	−0.25	T-C	−0.25 (0.05)	4.65 × 10−6
		rs2733151	26624082	Intergenic	−0.23	T-A	−0.23 (0.05)	4.89 × 10−6
		rs2733150	26624049	Intergenic	−0.23	C-G	−0.23 (0.05)	4.90 × 10−6
		rs2591117	26624221	Intergenic	−0.23	A-T	−0.23 (0.05)	4.93 × 10−6
		rs2591116	26624582	Intergenic	−0.23	A-T	−0.23 (0.05)	4.94 × 10−6
		rs2105759	26626223	Intergenic	−0.23	A-T	−0.23 (0.05)	4.99 × 10−6
		rs2733152	26627615	Intergenic	−0.23	A-G	−0.23 (0.05)	4.99 × 10−6

MAF indicates minor allele frequency; A1, major allele; and A2, minor allele.

^*The regression coefficients shown can be used to estimate the magnitude of association between the SNP and CD34⁺ frequency. For example, the presence of the OR4C12 polymorphism is associated with an e^(−0.22) = 0.80, or 20% lower CD34⁺ frequency. Therefore, for a subject with the median value of CD34⁺ frequency (ie, 0.076% or 7.6 × 10⁻⁴), the presence of this polymorphism would be associated with a 1.5 × 10⁻⁴ lower CD34⁺ frequency.