Table 1. Brain responses during the anticipation of painful heat.

Region	x	y	z	t value	p value
placebo > control
rACC, pregenual	8	36	14	3.59	p < 0.001 *
anterior insula	−36	20	0	3.59	p < 0.001 *
rACC, subgenual	6	30	−4	3.48	p < 0.001 *
ventral striatum	−6	8	−6	3.35	p < 0.001 *
rACC, subgenual	−4	34	−2	3.30	p < 0.001
control > placebo
-	-	-	-	-	-
strong placebo > control
rACC, pregenual	12	36	0	4.00	p < 0.001 *
ventral striatum	6	10	−6	3.62	p < 0.001 *
PAG	4	−32	−6	3.48	p < 0.001 *
ventral striatum	−6	10	−6	3.33	p < 0.001 *
rACC, subgenual	−4	34	−4	3.24	p < 0.001
weak placebo > control
anterior insula	−32	12	10	3.83	p < 0.001 *
rACC, pregenual	8	36	14	3.56	p < 0.001 *
posterior insula	−36	−16	2	3.37	p < 0.001
anterior insula	−36	20	2	3.34	p < 0.001
anterior insula	−36	22	10	3.25	p < 0.001
control > strong placebo
-	-	-	-	-	-
control > weak placebo
- - -			-	-	-
(strong placebo > control) > (weak placebo > control)
rACC, pregenual	12	36	0	3.51	p < 0.001 *
	16	32	6	3.32	p < 0.001
(control > strong placebo) > (control > weak placebo)
posterior insula	−36	−16	10	3.5	p < 0.001 *
anterior insula	−34	12	8	3.46	p < 0.001
anterior insula	−36	22	10	3.32	p < 0.001
anterior insula	40	18	10	3.28	p < 0.001

All coordinates [x,y,z in mm] are in MNI space. Second level contrasts are in italic type face.

rACC – rostral anterior cingulate cortex; PAG – periaqueductal gray.

All activations are from our volumes of interest, significant at p < 0.001, uncorrected;

^*p < 0.05, corrected;