Table 2. Brain responses during early and late pain.

Region	x	y	z	t value	p value
Early pain
placebo > control
rACC, pregenual	12	34	2	4.21	p < 0.001 *
rACC, pregenual	−6	34	8	3.76	p < 0.001 *
DLPFC	−42	44	26	3.61	p < 0.001
anterior insula	−40	24	6	3.19	p < 0.001
control > placebo
DLPFC	−44	18	30	3.39	p < 0.001
strong placebo > control
rACC, pregenual	−8	32	8	3.47	p < 0.001 *
anterior insula	−40	24	6	3.32	p < 0.001
weak placebo > control
rACC, pregenual	12	34	2	3.33	p < 0.001
DLPFC	38	32	36	3.15	p < 0.001
control > strong placebo
-	-	-	-	-	-
control > weak placebo
-	-	-	-	-	-
(strong placebo > control) > (weak placebo > control)
rACC, subgenual	−4	34	−4	3.45	p < 0.001 *
rACC, pregenual	−10	30	10	3.22	p < 0.001
(control > strong placebo) > (control > weak placebo)
-	-	-	-	-	-
Late pain
placebo > control
-	-	-	-	-	-
control > placebo
SII	32	−8	20	3.77	p < 0.001 *
Thalamus	−16	−22	6	3.45	p < 0.001 *
strong placebo > control
-	-	-	-	-	-
weak placebo > control
Thalamus	−12	−14	2	3.42	p < 0.001 *
control > strong placebo
dACC	10	4	40	3.26	p < 0.001
dACC	−6	4	38	3.24	p < 0.001
control > weak placebo
DLPFC	36	34	20	4.28	p < 0.001 *
(strong placebo > control) > (weak placebo > control)
DLPFC	36	34	20	3.98	p < 0.001 *
DLPFC	48	30	28	3.17	p < 0.001
(control > strong placebo) > (control > weak placebo)
rACC, subgenual	−12	30	−16	3.65	p < 0.001 *
thalamus	−12	−16	2	3.64	p < 0.001 *
posterior insula	−36	−16	6	3.48	p < 0.001 *
thalamus	8	−22	4	3.36	p < 0.001 *
thalamus	−8	−20	6	3.25	p < 0.001 *

All coordinates [x,y,z in mm] are in MNI space. Second level contrasts are in italic type face.

rACC – rostral anterior cingulate cortex; DLPFC – dorsolateral prefrontal cortex; SII – secondary somatosensory cortex; dACC – dorsal anterior cingulate cortex.

All activations p < 0.001, uncorrected, are from our volumes of interest;

^*p < 0.05 corrected.