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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Oct 30;1830(5):3317–3328. doi: 10.1016/j.bbagen.2012.10.018

Figure 3. Effect of mitochondrial cholesterol deposition on mitochondrial control of cell death.

Figure 3

In healthy mitochondria, mGSH levels can cope with the ROS generated after an apoptotic stimulus. However, in cholesterol enriched mitochondria, the mGSH transport is concomitantly decreased resulting in mGSH depletion. mGSH levels below a certain threshold will compromise ROS detoxification leading to its accumulation resulting ultimately in cardiolipin oxidation and cell death.