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. 2013 Feb 8;154(3):1092–1104. doi: 10.1210/en.2012-2098

Figure 6.

Figure 6.

Body weight in cross C (XY* model) mice before and after gonadectomy (GDX) at day 60. A, Before GDX, the 2 groups with testes were heavier than the 3 groups with ovaries. Nineteen weeks after GDX, mice with more than 1 sex chromosome (XX, XY, XXY) were heavier than mice with 1 X chromosome (XO or XO+PAR) (F(1,50) = 7.19, P < .01). Groups sizes: XO (6), XX (11), XO+PAR (11), XY (12), and XXY (12). B, In a second cohort of XY* model mice, 4 weeks after GDX, body weight was greater in mice with more than 1 sex chromosome than in mice with 1 X chromosome, and greater in pairwise comparisons of XXY or XY mice relative to mice with 1 X chromosome (XO+PAR). C, The cohort of mice shown in B was fed HFD for 16 weeks beginning 4 weeks after GDX. All groups increased body weight, but XX mice increased more and became as heavy as XXY mice, significantly heavier than the 2 groups of mice with 1 X chromosome. *P < .05, ***P < .001, ‡P < .00001.