Figure 3.

Manganese supplementation does not improve glucose tolerance but increases β-cell function in 129/SvEvTac mice on normal chow. Saline or Mn was administered to the mice for 7 days consecutively. A, Glucose (1 g/kg body weight) was injected ip and tail blood glucose levels were determined at the indicated times. B, Serum insulin levels were determined before and 30 minutes after glucose challenge. C, HOMA-IR. D, HOMA-B. A and B were analyzed by the bivariate ANOVA (2 way ANOVA). Different letters show statistical difference (P < .05). C and D were analyzed by the Student t test (2 tail), comparing difference between saline-IP vs MN-IP groups. * P < .01 (n = 15–18 mice/group).