Table 4.

Univariate and multivariate Cox proportional hazard analysis of overall survival and relapse-free survival

Characteristic	OS				RFS
	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
KRAS mutations (G>A vs. wild-type and not G>A)	2.06 (1.00, 4.25)	0.049	1.14 (0.51, 2.53)	0.748	2.07 (0.95, 4.54)	0.068	1.59 (0.65, 3.88)	0.309
Sex (Female vs. Male)	1.01 (0.50, 2.05)	0.986	1.16 (0.55, 2.48)	0.694	0.72 (0.33, 1.57)	0.408	0.90 (0.38, 2.16)	0.812
Age (≥60 vs. <60)	1.17 (0.55, 2.47)	0.685	1.37 (0.62, 3.04)	0.442	0.44 (0.21, 0.93)	0.032	0.44 (0.19, 1.00)	0.050
Stage (late vs. early)	3.09 (1.27, 7.55)	0.013	2.34 (0.88, 6.22)	0.089	4.31 (1.48, 12.59)	0.008	2.57 (0.80, 8.31)	0.115
Differentiation (Poor vs. Well/moderate)	2.68 (1.26, 5.71)	0.011	2.05 (0.94, 4.46)	0.071	3.67 (1.59, 8.48)	0.002	3.04 (1.28, 7.19)	0.011
Chemotherapy/radiotherapy (yes vs. no)	3.52 (1.33, 9.31)	0.011	2.80 (1.02, 7.69)	0.046	4.21 (1.41, 12.51)	0.010	2.88 (0.95, 8.73)	0.061
MSI status (MSS vs. MSI)	2.39 (0.83, 6.83	0.105	2.74 (0.95, 7.91)	0.063	2.97 (0.89, 9.87)	0.076	3.62 (1.06, 12.29)	0.039

OS, overall survival; RFS, relapse-free survival; HR, hazard ratio; CI, confidence interval; MSS, microsatellite stable; MSI, microsatellite instability