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. 2013 Mar;93(3):377–385. doi: 10.1189/jlb.0812395

Table 2. Changes in ISG Expression Levels in Human Hepatocytes after Treatment with IFN-λ1 or IFN-α2a for 24 h.

Gene symbol RefSeq Fold increase
Gene description
IFN-λ1 IFN-α2a
IFIT1 NM_001548 64.53 241.52 IFN-induced protein with tetratricopeptide repeats 1
CXCL10 NM_001565 54.27 795.65 Chemokine (C-X-C motif) ligand 10
MX2 NM_002463 29.90 107.34 Myxovirus (influenza virus) resistance 2 (mouse)
ISG15 NM_005101 29.49 121.60 IFN-stimulated gene 15 ubiquitin-like modifier
IFITM1 NM_003641 25.67 89.02 IFN-induced transmembrane protein 1 (9–27)
IFIT3 NM_001549 17.53 65.62 IFN-induced protein with tetratricopeptide repeats 3
IFI6 NM_002038 16.36 28.36 IFN, α-inducible protein 6
MX1 NM_002462 12.23 17.83 Myxovirus (influenza virus) resistance 1
OAS1 NM_002534 9.79 20.76 2′,5′-Oligoadenylate synthetase 1, 40/46 kDa
IFIH1 NM_022168 8.89 24.18 IFN induced with helicase C domain 1
OAS2 NM_002535 7.53 12.60 2′,5′-Oligoadenylate synthetase 2, 69/71 kDa
IFI16 NM_005531 7.42 18.58 IFN, γ-inducible protein 16
STAT1 NM_007315 7.42 14.68 STAT 91 kDa
ISG20 NM_002201 7.17 25.92 IFN-stimulated exonuclease gene 20 kDa
IRF7 NM_001572 6.24 12.26 IFN regulatory factor 7
IFI27 NM_005532 6.03 22.88 IFN, α-inducible protein 27
EIF2AK2 NM_002759 5.28 7.14 Eukaryotic translation initiation factor 2-α kinase 2
HLA-DOA NM_002119 4.41 14.99 MHC, Class II, DO α
TNFSF10 NM_003810 4.32 19.51 TNF (ligand) superfamily, member 10
TAP1 NM_000593 4.03 7.60 Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP)
IFNA4 NM_021068 3.90 5.76 Interferon, α 4
STAT2 NM_005419 3.79 9.68 STAT2, 113 kDa
CD70 NM_001252 3.14 5.30 CD70 molecule
NMI NM_004688 2.81 5.68 N-myc (and STAT) interactor
BST2 NM_004335 2.61 7.04 Bone marrow stromal cell antigen 2
SAMSN1 NM_022136 2.55 5.56 Sterile α motif domain, Src homology 3 domain and nuclear localization signals 1
GBP1 NM_002053 2.35 4.49 Guanylate-binding protein 1, IFN-inducible, 67 kDa
ARL5B NM_178815 2.28 3.70 ADP-ribosylation factor-like 5B
IRF9 NM_006084 2.25 3.50 IFN regulatory factor 9
HLA-F NM_018950 2.07 7.39 MHC Class I, F