Fig. 2.

Effects of PKCδ and PKCε inhibitors on facilitation of LTP by PMA. (A) The potentiating effect of PMA (200 nM) was blocked in the presence of Ro 31-8220 (10µM; a nonspecific PKC inhibitor), (B) rottlerin (1µM; a selective PKCδ inhibitor), and (C) TAT-εV1-2 peptide (500 nM; a PKCε inhibitor). (D) Averaged values from 58 to 60 min after a single episode of TBS from the experiment reported in A, B and C, are represented in bar graph form. All values are expressed as means±SEMs (error bars). Values in parentheses are numbers of animals and slices tested. ^*p<0.05 compared to vehicle. Rot, rottlerin; εV1-2, TAT-εV1-2.