Fig. 1.

Effects of MPTP (30 mg/kg, s.c) on Rota-rod performance. Animals were trained to stay on an operating Rota-rod for 600 seconds. On the test day, animals were evaluated on the Rota-rod 6 and 24 hours after MPTP administration. (A) MPTP (C57BL/6, 30 mg/kg, s.c.), (B) MPTP (ICR, 30 mg/kg, s.c.), (C) MPTP (C57BL/6, ICR, Balb C, 20 mg/kg, s.c.), (D) body weight after MPTP administration. Data are expressed as mean latency to fall off the Rota-rod (vertical bars represent standard error of the mean). ^*p<0.05, ^**p<0.01 vs 0 hour (naïve) group, ^#p<0.05 compared between 6 hours and 24 hours groups by Student's t-test, n=6~10.