TABLE I.
Association results of the top SNPs in SARP/CSGA/CAG populations with asthma
| SNP | Gene | Chromosome | BP | Location | MAF | OR (95% CI) | P value* | ||
|---|---|---|---|---|---|---|---|---|---|
| SARP/CSGA/CAG | TENOR6 | GABRIEL3 | |||||||
| rs1422673 | TNIP1 | 5 | 150419181 | Intron | T (0.198) | 0.63 (0.53-0.75) | 3.44E-07 | .18 | .018 |
| rs10036748 | TNIP1 | 5 | 150438339 | Intron | T (0.260) | 0.68 (0.58-0.79) | 1.41E-06 | .41 | .11 |
| rs2791189 | ADAMTS14 | 10 | 72187212 | Intron | C (0.361) | 0.69 (0.60-0.80) | 5.73E-07 | .16 | .54 |
| rs946742 | ADAMTS14 | 10 | 72185697 | Intron | C (0.423) | 0.74 (0.65-0.85) | 2.10E-05 | .73 | .74 |
| rs3755285 | IL1RL2 | 2 | 102210452 | Intron | G (0.267) | 1.41 (1.21-1.63) | 6.19E-06 | .022 | .023 |
| rs12619383 | IL1R1 | 2 | 102108150 | Flanking_5 | G (0.182) | 0.68 (0.57-0.81) | 2.99E-05 | .2 | 2.16E-05 |
| rs2073838 | SLC22A4 | 5 | 131677121 | Intron | A (0.082) | 1.79 (1.41-2.26) | 1.59E-06 | .39 | .51 |
| rs2306772 | SLC22A4 | 5 | 131703880 | Intron | A (0.082) | 1.76 (1.40-2.23) | 2.65E-06 | .41 | .48 |
BP, Base pair position based on hg18; MAF, minor allele frequency.
*
Genomic control–adjusted P values for SARP/CSGA/CAG, TENOR, and GABRIEL.