TABLE III.
Comparison of IL13, TNIP1, GSDMB, HLA-DRA, SMAD3, LRRC32, and IKZF4 from the GWAS of asthma and autoimmune diseases
| Gene/SNP | Minor/major allele | GWASs | Function | |
|---|---|---|---|---|
| IL13 | Asthma (TENOR6 and GABRIEL3) | Psoriasis21 | TH2 | |
| rs20541 | T/C | T is minor risk allele | T is minor protective allele | |
| TNIP1 | Asthma (SARP/CSGA/CAG and GABRIEL3) | SLE25,26 and systemic sclerosis27 | Inflammation | |
| rs10036748 | T/C (white subjects) | T is minor protective allele | T is minor risk allele (white subjects)25,27 | |
| GSDMB | C/T (Chinese subjects) | NAAsthma (SARP/CSGA/CAG and TENOR6 and GABRIEL3) | T is major risk allele (Chinese subjects)26RA,22 CD,23 and UC24 | Inflammation? |
| rs2872507 | A/G | A is minor protective allele | A is minor risk allele | |
| HLA-DRA | Asthma (SARP/CSGA/CAG and TENOR6 and GABRIEL3) | UC28 | Antigenpresentation | |
| rs2395185 | T/G | T is minor risk allele | T is minor protective allele | |
| SMAD3 | Asthma (SARP/CSGA/CAG and GABRIEL3) | CD29 | Treg | |
| rs16950687 | G/A | G is minor risk allele | NA | |
| rs17293632 | T/C | NA | T is minor risk allele | |
| LRRC32 | Asthma20 | CD23 | ||
| rs7130588 | G/A | G is minor risk allele | NA | |
| rs7927894 | T/C | NA | T is minor risk allele | Treg? |
| IKZF4 | Asthma7 | T1D30 | ||
| rs1701704 | G/T | G is minor risk allele | G is minor risk allele | Treg? |
CD, Crohn disease; NA, not applicable; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; T1D, type I diabetes; Treg, regulatory T; UC, ulcerative colitis.