Table 1.

CYP2C9 polymorphisms in populations of African descent

Polymorphisms			Populations
rs#	Nucleotide change	Effect	African				African-American		Brazilian
	(allele)		Cohort (n)	Frequency (%)	Reference	n	Freqency (%)	Reference	Cohort (n)	Frequency (%)	Reference
rs1799853	430C > T (*2)	R144C	Beninese (103)	0	[20]	1889	0–3.6	[23, 26, 27, 29, 30, 40, 54–56]	>80% African ancestry (65)	3.1	[57]
			Mozambican (103)	0	[58]				Black (756)	6.6	[19, 59]
			South African (923)	0	[60]				Brown (816)	8.2, 9.3	[19, 59]
rs1057910	1075A > C (*3)	I359L	Beninese (103)	0	[20]	1938	0.3–2.0	[23, 26, 27, 29, 30, 40, 54–56, 61]	>80% African ancestry (65)	2.3	[57]
			Mozambican (103)	1.0	[58]				Black (756)	2.6, 3.3	[19, 59]
			South African (213)	0.5	[22]				Brown (816)	5.1, 5.9	[19, 59]
rs28371686	1080C > G (*5)	D360E	Beninese (103)	1.8	[20]	1464	0.7–1.5	[23, 26, 27, 29, 30, 55, 56]	>80% African ancestry (65)	2.3	[57]
			Mozambican (103)	1.9	[58]				Black (756)	0, 0.9	[19, 59]
			South African (213)	0	[22]				Brown (816)	0.5, 0.8	[19, 59]
rs9332131	818delA (*6)	273 frameshift	Beninese (103)	2.7	[20]	1051	0.4–1.7	[23, 24, 29, 40, 55, 56]
			Mozambican (103)	0	[58]
			South African (213)	0.2	[22]
rs7900194	449G > A (*8)	R150H	Beninese (103)	8.6	[20]	1111	4.7–7.2	[23, 26, 27, 40]	Black (76)	4.7	[58]
			Mozambican (103)	10.8	[58]				Brown (118)	0.4	[58]
			South African (213)	13.3	[22]
rs2256871	752A > G (*9)	H251R	Beninese (103)	15.7	[20]
			South African (213)	15.1	[22]
rs28371685	1003A > G (*11)	R335W	Beninese (103)	2.7	[20]	1541	1.0–4.0	[23, 26, 27, 29, 40, 55, 56, 61]	Black (756)	0.7, 0.9	[19, 59]
			Mozambican (103)	2.4	[58]				Brown (816)	0, 0.5	[19, 59]
			South African (213)	3.9	[22]
rs2860905	3858G > A	intron 3	YRI (111)	26.6	61	378	22.0, 24.5	[26, 61]
rs7089580	6787A > T	intron 3	YRI (213)	21.2	61	612	19.4–23.0	[26, 27, 61]
	7880T > C	intron 3				329	2.0	[26]
rs35511771	13706T > C	intron 5				329	24.0	[26]
	46028A > G	intron 7	South African (213)	28.8	[22]

n, number of individuals.