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. 2012 Jun 7;75(2):334–346. doi: 10.1111/j.1365-2125.2012.04354.x

Table 2.

VKORC1 polymorphisms in populations of African descent

Polymorphisms Populations
rs# Nucleotide change Effect African African-American Brazilian
Cohort (n) Frequency (%) Reference n Frequency (%) Reference Cohort (n) Frequency (%) Reference
rs9923231 3673G > A 5'UTR Mozambican (143) 3.5 [9] 1754 8.8–22.0 [23, 26, 27, 31, 33, 40, 42, 56, 61] Black (756) 22.0, 23.8 [19, 59]
Angolan (73) 2.7 [9] Brown (816) 30.6, 33.0 [19, 59]
Black, 4 continents (368) 10.1 [17] >80% African ancestry (68) 21.1 [9]
rs9934438 6484C > T intron 1 South African (993) 4.0 [60] 1267 8.0–12.0 [26, 29, 31, 40, 42, 49, 55, 61]
Beninese (51) 2.0 [62]
Black, 4 continents (368) 10.2 [17]
rs8050894 6853G > C intron 2 Mozambican (143) 27.3 [9] 849 20.4–30.0 [26, 2932] Black (756) 35.7, 36.0 [19, 59]
Black, 4 continents (368) 26.4 [17] Brown (816) 38.0, 38.6 [19, 59]
Angolan (73) 19.2 [9] >80% African ancestry (68) 34.4 [9]
rs2884737 5808T > G intron 1 Mozambican (143) 1.1 [9] 698 3.5–7.1 [24, 33, 55, 61] Black (756) 10.0, 12.8 [19, 59]
Angolan (73) 0 [9] Brown (816) 13.5, 20.0 [19, 59]
>80% African ancestry (68) 10.7 [9]
rs7294 9041G > A 3'UTR South African (991) 40.0 [60] 973 44.0–52.3 [24, 26, 29, 32, 55, 61] Black (756) 37.9, 41.0 [19, 59]
Mozambican (143) 38.9 [9] Brown (816) 37.2, 39.0 [19, 59]
Angolan (73) 40.4 [9] >80% African ancestry (68) 46.9 [9]
rs17886199 6915C > T intron 2 258 3.7 [33]
rs59502288 1989_1990insTGGATGA 5'UTR 329 42.0 [26]
rs62057090 5374C > G 5'UTR 329 29.0 [26]
rs61162043 6051G > A 5'UTR 570 47.0, 48.3 [26, 27]
rs2359612 7566C > T intron 2 South African (974) 24.0 [60] 804 15.9–23.3 [26, 29, 32, 40, 61]
rs7200749 8773G > A L120L South African (113) 25.7 [22] 353 18.2–26.5 [32, 33, 61]
rs72547529 6557C > T V66M South African (110) 0.4 [22] 509 0–1.6 [23, 40, 55]

n, number of individuals.