Table 1.
Effect of curcuminoid/piperine co-administration on the pharmacokinetics of midazolam and 1'-OH-midazolam
| Mean ± SD (n = 8) | P value* | Geometric mean ratio (90% CI) | ||
|---|---|---|---|---|
| Placebo | Curcuminoid/ piperine | |||
| Midazolam | ||||
| Cmax (ng ml−1) | 10.1 ± 6.1 | 9.9 ± 5.2 | 0.61 | 0.97 (0.79, 1.20) |
| tmax (h) | 1.3 ± 0.3 | 1.2 ± 0.6 | 1.00 | |
| t1/2 (h) | 2.2 ± 0.4 | 2.2 ± 0.3 | 0.73 | |
| AUC(0,∞) (ng ml−1 h) | 37.8 ± 31.5 | 34.0 ± 23.4 | 0.32 | 0.91 (0.75, 1.11) |
| Clearance (ml min−1) | 1776 ± 725 | 2028 ± 1134 | 0.32 | |
| Clearance (ml min−1 kg−1) | 23.6 ± 11.0 | 27.0 ± 16.0 | 0.20 | |
| 1'-OH-midazolam | ||||
| Cmax (ng ml−1) | 3.4 ± 2.2 | 5.0 ± 3.0 | 0.03 | |
| tmax (h) | 1.2 ± 0.3 | 1.2 ± 0.6 | 0.75 | |
| AUC(0,∞) (ng ml−1 h) | 12.3 ± 11.2 | 16.4 ± 12.8 | 0.07 | |
*
Statistical comparisons were made with the Student's paired t-test on rank-transformed values.