Table 3.
Statistical analysis of the primary pharmacokinetic parameters
| Parameter | Geometric mean | Ratio of treatment means (eribulin plus rifampicin: eribulin) | 90% confidence interval | |
|---|---|---|---|---|
| Eribulin plus rifampicin | Eribulin | |||
| AUC(0,∞) (ng ml–1 h) | 789 | 716 | 1.10 | 0.91, 1.34 |
| Cmax (ng ml–1) | 333 | 342 | 0.97 | 0.81, 1.17 |
Model includes terms for treatment, and patient (n = 11 patients). AUC(0,∞), area under the concentration−time curve from zero (pre-dose) extrapolated to infinity; Cmax, maximum observed plasma concentration.