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. 2013 Jan 16;168(3):576–590. doi: 10.1111/j.1476-5381.2012.02234.x

Figure 3.

Figure 3

USPs promote lysosomal degradation and recycling of GPCRs. (A) (1) USPs cleave ubiquitin molecules from GPCRs to (2) promote entry in lysosomes and degradation by lysosomal peptidases or (3) recycling of GPCRs to the cell-surface mediating resensitization of signalling. (B) Ubiquitination of β-arrestins promotes GPCR-mediated phosphorylation of extracellular-regulated PK 1 and 2. (2) De-ubiquitination of β-arrestins by USPs destabilizes the GPCR•β-arrestin complex to terminate ERK1/2 activation.