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. 2013 Feb;15(2):133–142. doi: 10.1593/neo.121758

Figure 3.

Figure 3

Differences in angiogenic factor production based on NSCLC subtype. CD3-CD56+CD16- NK cells from patients with SCC produce significantly more VEGF than those from patients with AdC. This was evident both locally in the tumor and in the adjacent tissues. This effect appeared to be systemic, as CD3-CD56+CD16- NK cells from patients with SCC showed significantly higher production of VEGF when compared to patients with AdC or to healthy donor controls [HC, eight donors with a median age of 54; range, 44 to 68; 63% male and 25% smokers (open diamonds, ⋄) and four anonymous donors (filled diamonds, ♦)]. In addition, CD3-CD56+CD16- NK cells from peripheral blood and adjacent tissue from patients with SCC produced significantly more PlGF. In the peripheral blood, patients with both SCC and AdC showed significantly higher production of IL-8 and IFN-γ compared to healthy controls. While there was no difference in IL-8 production between NK cells from patients with AdC and SCC, those with SCC showed significantly higher production of IFN-γ compared to AdC. ****P < .0001, ***P < .001, **P < .01, *P < .05; ns, not significant.