FIG. 7.

Real-time polymerase chain reaction (RT-PCR) analysis of growth-associated protein (GAP)-43, synaptophysin (SYN), and brain-derived neurotrophic factor (BDNF). Tissues were collected at regions labeled in A. 1: cortex of injury side; 2: cortex of contralateral side (uninjured side); 3: hippocampus of injury side; 4: hippocampus of contralateral side (uninjured side). (B) RT-PCR showed increased expression of GAP-43 in knockout (KO) mice, especially in the hippocampus of bilateral hemispheres (p=0.042 for the hippocampus of the uninjured side; p=0.041 for the hippocampus of the injury side.). No significant change in BDNF and SYN expression levels were observed (C,D). (Data presented as mean±SEM, n=5 for WT; n=6 for KO.)