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. 2013 Apr 1;18(10):1208–1246. doi: 10.1089/ars.2011.4498

FIG. 1.

FIG. 1.

The suggested effects of endurance capacity-mediated evolution on the human body. Early human endurance running was important for successful hunting, and high endurance capacity affected metabolism and redox adaptation. On the other hand, modern lifestyle physical inactivity acts against the build-up of endurance capacity. A low level of maximal oxygen uptake is a risk factor for a number of diseases and increases the rate of mortality. VO2max., maximal oxygen uptake.