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Models for activation of MOMP effectors. (A) Derepressor model. (B) Direct activator model. (C) Current model, which is a refinement of the two former models. Antiapoptotic Bcl-2-like Bcl-XL proteins inhibit both direct activator BH3-proteins (MODE1) and effectors Bax and Bak (MODE2). Inhibition through Bcl-XL is relieved by sensitizer BH3-only proteins.
