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The order of events leading to MOMP. At first, an activator BH3 protein like tBid is targeted to the membrane (Step 1), which binds and recruits Bax to the membrane (Step 2). Upon activation, Bax exposes its carboxy-terminal membrane-anchor helix and becomes membrane integrated (Step 3). Activated Bax homo-oligomerizes (Step 4), which causes the formation of pores so that proapoptotic contents of the mitochondrial intermembrane space like cytochrome c can be released (Step 5).
