Table 1.

Viral proteins acting at EBV’s characterized origins and their functions

Origin	Protein	Function
oriP	EBNA1	1. Origin-binding protein at the DS element; recruits ORC for licensed DNA replication 2. Binds FR element to mediate maintenance of the plasmid replicon
oriLyt	BZLF1	1. Origin-binding protein of oriLyt that can bind multiple viral replication proteins 2. Viral transcription factor required to initiate the lytic phase of EBV and support expression of viral factors of lytic DNA amplification
	BALF5	DNA polymerase catalytic subunit; interacts with the helicase–primase complex (Fujii et al. 2000)
	BALF2	Single-stranded DNA-binding protein
	BMRF1	DNA polymerase accessory subunit with a PCNA-like structure (Murayama et al. 2009; Nakayama et al. 2010); interacts with BALF5 (Tsurumi et al. 1993); can act as a transcriptional coactivator of BZLF1 (Nakayama et al. 2009)
	BBLF4	DNA helicase
	BSLF1	Primase
	BBLF2/3	Primase-associated factor. BBLF4, BSLF1, and BBLF2/3 form the helicase–primase complex