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. 2013 Feb 13;12:31–51. doi: 10.4137/CIN.S10329

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© 2013 the author(s), publisher and licensee Libertas Academica Ltd.

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Figure 6. — Subnetwork enrichment analysis of upstream transcriptional and post-transcriptional regulators. (A) 12 microRNAs (yellow nodes) were significantly enriched with targets (experimentally validated and/or predicted) among 44 genes (red nodes) from the intersection list. Only 3 interactions in this network are computationally predicted: miR-132 with BRCA1; miR-27B with NEK2; and miR-98 with DUSP4. These 3 predicted interactions are shown as dotted lines in grey color. All other interactions in this network are experientially validated (Tarbase 6.0) and shown as blue dotted lines. (B) Top three transcription factors regulating microRNA regulatory subnetwork (based on enrichment analysis of known transcription factors).