Table 3.
Top 20 biological processes as a result of GO enrichment analysis for 44 DEGs from intersection set.
| Name | Total entities | Overlap | Percent overlap | Overlapping entities | P-value |
|---|---|---|---|---|---|
| Cell cycle | 604 | 23 | 3 | PLK1, PTTG1, BRCA1, CDC25C, BUB1B, CCNB2, AURKA, UBE2S, TPX2, SPAG5, UBE2C, KIFC1, MCM2, RACGAP1, PRC1, NEK2, FANCI, TIMELESS, DSCC1, CDCA3, CDKN3, DIXDC1, KIF18B | 5.23E-29 |
| Cell division | 336 | 18 | 5 | PLK1, PTTG1, CCNB1, CDC25C, BUB1B, CCNB2, AURKA, UBE2S, TPX2, SPAG5, UBE2C, KIFC1, RACGAP1, PRC1, NEK2, TIMELESS, CDCA3, KIF18B | 4.96E-25 |
| Mitosis | 252 | 15 | 5 | PLK1, PTTG1, CDC25C, BUB1B, CCNB2, AURKA, TPX2, SPAG5, UBE 2C, KIFC1, NEK2, TIMELESS, CDCA3, KIF15, KIF18B | 1.72E-21 |
| Mitotic cell cycle | 316 | 14 | 4 | PLK1, PTTG1, CCNB1, CDC25C, BUB1B, CCNB2, AURKA, UBE2C, MCM2, CENPA, NEK2, GINS2, KIF18A, KIF18B | 2.98E-18 |
| Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 90 | 7 | 7 | PLK1, PTTG1, CCNB1, BUB1B, AURKA, UBE2S, UBE2C | 2.99E-11 |
| Microtubule-based movement | 121 | 6 | 4 | KIFC1, RACGAP1, KIF4A, KIF18A, KIF15, KIF18B | 1.31E-08 |
| Spindle organization | 22 | 4 | 18 | BUB1B, AURKA, SPAG5, UBE2C | 1.95E-08 |
| Cell cycle checkpoint | 141 | 6 | 4 | CCNB1, CDC25C, BUB1B, CCNB2, UBE2C, MCM2 | 3.28E-08 |
| Chromosome segregation | 75 | 5 | 6 | PTTG1, ESPL1, BRCA1, TOP2A, NEK2 | 5.26E-08 |
| Phosphatidylinositol-mediated signaling | 77 | 5 | 6 | BUB1B, AURKA, SPAG5, UBE2C, TOP2A | 6.00E-08 |
| Mitotic prometaphase | 90 | 5 | 5 | PLK1, CCNB1, BUB1B, CENPA, KIF18A | 1.32E-07 |
| DNA replication | 179 | 6 | 3 | BRCA1, CDC25C, MCM2, TOP2A, GINS2, DSCC1 | 1.35E-07 |
| M phase of mitotic cell cycle | 96 | 5 | 5 | PLK1, CDC25C, BUB1B, CENPA, KIF18A | 1.82E-07 |
| G2-M transition of mitotic cell cycle | 116 | 5 | 4 | PLK1, CCNB1, CDC25C, CCNB2, NEK2 | 4.69E-07 |
| Mitotic sister chromatid segregation | 14 | 3 | 21 | ESPL1, KIFC1, NEK2 | 7.91E-07 |
| Cytokinesis | 60 | 4 | 6 | PLK1, ESPL1, RACGAP1, PRC1 | 1.25E-06 |
| Cell proliferation | 429 | 7 | 1 | PLK1, CDC25C, BUB1B, TPX2, ZFP36L2, CSE1L, KIF15 | 1.46E-06 |
| Free ubiquitin chain polymerization | 2 | 2 | 100 | UBE2S, UBE2C | 1.73E-06 |
| Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 77 | 4 | 5 | PLK1, CCNB1, BUB1B, UBE2C | 3.42E-06 |
| Homologous chromosome segregation | 4 | 2 | 50 | PTTG1, ESPL1 | 1.04E-05 |