Fig. 1.

Plasma vincristine concentration following administration of 2 mg/m² of VCR (dashed lines) or VSLI (solid lines) to rats. Vincristine drug concentrations were measured in plasma from Sprague–Dawley rats (N = 3/sex, except at 120 h, N = 5) at the indicated timepoints post-dose of 2 mg/m² VSLI (solid lines) or vincristine (dashed lines). Symbols indicate the following: Male VCR (open circle), Female VCR (open square), Male VSLI (filled circle), Female VSLI (filled square)