Table 5.

Pharmacokinetic parameters (a) acadesine, (b) ZMP

Cohort	Dose (mg/kg)	t max (h)	C max (ng/mL)	AUC(0→24h) (ng h/mL)	t ½ (h)
(A)
Part I
1	50
	Median	4.0	4,325	14,251	5.2
	Minimum	3.7	2,930	9,800	1.0
	Maximum	4.3	8,139	21,213	45.4
2	83.5
	Median	4.1	6,888	24,614	35.0
	Minimum	4.1	5,148	15,986	5.2
	Maximum	4.5	10,036	32,534	79.4
3	139.5
	Median	4.0	12,439	39,503	25.3
	Minimum	3.9	2,449	11,549	3.8
	Maximum	4.0	30,574	89,015	28.5
4	210
	Median	4.0	38,736	123,125	16.2
	Minimum	4.0	30,431	118,235	10.2
	Maximum	4.1	64,672	240,500	35.7
5	315
	Median	4.5	35,170	240,403	61.4
	Minimum	4.2	33,855	171,809	2.6
	Maximum	4.7	65,536	275,298	62.0
Part II
6	2 × 210
	Day 1
	Median	4.1	41,851	195,556	24.6
	Minimum	4.0	7,177	26,315	14.2
	Maximum	4.4	68,366	228,532	25.8
	Day 4
	Median	4.2	28,774	126,430	98.8
	Minimum	4.0	2,213	14,858	18.8
	Maximum	4.5	45,939	149,534	106.2
7	5 × 210
	Day 1
	Median	4.3	49,533	161,939	3.9
	Minimum	4.3	41,619	117,843	3.0
	Maximum	4.6	54,892	198,014	12.0
	End of treatment
	Median	4.1	51,456	198,646	56.2
	Minimum	4.0	51,160	148,617	3.8
	Maximum	4.2	67,684	231,356	65.1
(B)
Part I
1	50
	Median	4.3	52,101	312,131	72.3
	Minimum	3.67	7,666	20,438	0.5
	Maximum	5.03	93,198	424,582	239.9
2	83.5
	Median	4.5	73,023	562,247	35.1
	Minimum	4.08	71,775	360,973	34.5
	Maximum	5.08	76,814	577,760	95.2
3	139.5
	Median	4.0	114,001	1,023,992	66.4
	Minimum	4.00	94,144	701,177	17.6
	Maximum	4.58	156,663	1,343,691	91.2
4	210
	Median	4.1	270,988	2,066,170	39.8
	Minimum	4.00	185,258	1,910,548	22.2
	Maximum	5.08	295,124	2,159,142	118.2
5	315
	Median	4.5	243,540	2,434,242	8.1
	Minimum	4.17	157,154	1,472,810	5.7
	Maximum	4.68	342,195	2,873,273	111.7
Part II
6	2 × 210
	Day 1
	Median	4.1	275,836	2,610,904	24.3
	Minimum	4.00	152,335	853,666	12.7
	Maximum	4.42	312,929	2,747,816	26.5
	Day 4
	Median	4.7	223,390	2,081,843	81.5
	Minimum	4.00	95,310	738,586	64.4
	Maximum	5.50	229,030	2,538,271	134.1
7	5 × 210
	Day 1
	Median	5.7	265,536	1,833,232	16.6
	Minimum	5.33	159,539	1,056,891	11.4
	Maximum	6.33	344,686	2,866,182	45.4
	End of treatment
	Median	4.2	188,936	1,942,209	71.3
	Minimum	4.00	108,108	870,256	16.2
	Maximum	5.08	265,657	2,152,337	98.1

T _max time of maximum drug concentration, C _max maximum drug concentration, AUC _0→24 area under the time–concentration curve from 0 to 24 h, t½ and half life