TABLE 3.

Incidence of hypertrophic actinic keratoses on the dorsal hands and forearms of cryotherapy plus imiquimod recipients relative to recipients of cryotherapy only

				NUMBER OF LESIONS		CHANGE FROM BASELINE IN NUMBER OF LESIONS VERSUS CONTROL
TREATMENT	NUMBER OF OBSERVATIONS	TIMEPOINT	NUMBER OF SUBJECTS	MEAN	SD	MEAN	SD	P-VALUEa
Cryotherapy plus imiquimod	20	Baseline	20	6.3000000	3.5850567	—	—	—
		Week 2	18	6.1666667	3.8994721	0.28	2.70	0.0913
		Week 4	18	5.3888889	3.8369548	−1.06	3.10	0.9248
		Week 6	17	3.6470588	2.9987743	−2.94	4.87	0.3816
		Week 10	15	1.8666667	1.3020131	−5.00	3.57	0.0169
		Week 14	17	1.5294118	1.4627734	−5.12	3.84	0.0094
Cryotherapy only	20	Baseline	20	5.5000000	2.5649459	—	—	—
		Week 2	19	4.3684211	2.4085617	−1.11	1.29	—
		Week 4	18	4.5000000	2.4554861	−1.00	2.33	—
		Week 6	17	3.5294118	2.2112679	−1.94	2.22	—
		Week 10	16	3.3750000	2.7049338	−2.13	2.78	—
		Week 14	17	3.3529412	2.8049326	−2.24	3.19	—

^aP-values were for the comparison, by way of ANOVA with factors of patient and treatment, of mean change from baseline at each week post-baseline for the cryotherapy plus imiquimod group compared to the corresponding week in the cryotherapy only group.