TABLE 4.
Incidence of non-hypertrophic actinic keratoses on the dorsal hands and forearms of cryotherapy plus imiquimod recipients relative to recipients of cryotherapy only
| NUMBER OF LESIONS | CHANGE FROM BASELINE IN NUMBER OF LESIONS VERSUS CONTROL | |||||||
|---|---|---|---|---|---|---|---|---|
| TREATMENT | NUMBER OF OBSERVATIONS | TIMEPOINT | NUMBER OF SUBJECTS | MEAN | SD | MEAN | SD | P-VALUEa |
| Cryotherapy plus imiquimod | 20 | Baseline | 20 | 7.6000000 | 5.3054094 | — | — | — |
| Week 2 | 18 | 5.5555556 | 4.5012707 | −1.06 | 3.81 | 0.2810 | ||
| Week 4 | 17 | 5.9411765 | 4.9177051 | ≈−0.59 | 3.86 | 0.0457 | ||
| Week 6 | 17 | 8.0588235 | 5.3673852 | 1.29 | 6.02 | 0.0178 | ||
| Week 10 | 15 | 4.9333333 | 4.5113613 | −2.00 | 4.69 | 0.8570 | ||
| Week 14 | 17 | 2.9411765 | 4.9177051 | −4.29 | 4.98 | — | ||
| Cryotherapy only | 20 | Baseline | 20 | 7.6000000 | 4.5468323 | — | — | — |
| Week 2 | 19 | 5.0526316 | 3.3743095 | −2.16 | 3.50 | — | ||
| Week 4 | 17 | 4.4444444 | 3.5183924 | −2.76 | 3.07 | — | ||
| Week 6 | 17 | 4.5294118 | 3.0437979 | −2.41 | 4.06 | — | ||
| Week 10 | 16 | 3.4375000 | 2.3935678 | −4.13 | 4.01 | — | ||
| Week 14 | 17 | 3.2352941 | 3.8653818 | −4.12 | 3.31 | — | ||
a
P-values were for the comparison, by way of ANOVA with factors of patient and treatment, of mean change from baseline at each week post-baseline for the cryotherapy plus imiquimod group compared to the corresponding week in the cryotherapy only group