FIG. 1.

Schematic illustrating the mechanisms of ischemic/reperfusional (I/R) injury and the effects of therapeutic hypothermia. We illustrate the schema of mechanisms of I/R brain injury and the effective point of hypothermia treatment. The pathology of I/R injury is approximately separated as two mechanisms, that is, the cell death after cellular dysfunction in ischemic phase, and the free radical production in reperfusion phase. The boxed arrow with entered “Hypothermia” means the estimated effective points in I/R cascade.