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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Mar;72(3):219–233. doi: 10.1097/NEN.0b013e3182859939

Figure 5.

Figure 5

The migration of human malignant peripheral nerve sheath tumor (MPNST) cells is enhanced in a concentration-dependent manner by multiple epidermal growth factor receptor (EGFR) ligands. Transwell migration assays in which human STS-26T (gray bars) and ST88-14 (black bars) MPNST cells were stimulated with vehicle or 0.1 to 100 nM concentrations of the EGFR ligands EGF, transforming growth factor-α (TGFα), amphiregulin, heparin-binding EGF (HB-EGF), betacellulin, epiregulin or epigen are shown. Numbers of cells migrating in wells receiving EGFR ligands are normalized to numbers of cells migrating in wells receiving vehicle. Bars represent the normalized average migration ± SEM. An asterisk above a bar indicates a different level of migration (p < 0.05) vs. cells challenged with vehicle.