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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Mar;72(3):219–233. doi: 10.1097/NEN.0b013e3182859939

Figure 6.

Figure 6

Exogenous epidermal growth factor receptor (EGFR) ligands variably enhance the migration of non-neoplastic Schwann cells in a concentration-dependent manner. Transwell migration assays in which rat Schwann cells were stimulated with vehicle or 0.1 to 100 nM concentrations of the EGFR ligands EGF, transforming growth factor-α (TGFα), amphiregulin, heparin-binding EGF (HB-EGF), betacellulin or epiregulin are shown. Epigen had no effect on the migration of non-neoplastic Schwann cells (not shown). Numbers of cells migrating in wells receiving EGFR ligands were normalized to the number of cells migrating in wells receiving vehicle. Bars represent the normalized average migration ± SEM. Asterisks above bars indicate a significant change in migration (p < 0.05) vs. cells challenged with vehicle.