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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: Circulation. 2012 Dec 5;127(2):213–223. doi: 10.1161/CIRCULATIONAHA.112.131110

Figure 4.

Figure 4

Preload, afterload and contractility changes following hCSC and hMSC therapy. (A) Left ventricle end-diastolic pressure (LVEDP) and (B) end-diastolic volume (EDV) as well as afterload measured by (C) arterial elastance (Ea). Combination hCSC / hMSC therapy (n=5) improved contractility as measured by the (D) maximal rate of pressure change during systole (dP/dtmax) as well as (E) preload recruitable stroke work (PRSW), a preload independent measure of stroke work. There was no change in (F) systolic elastance (Ees), the slope of the end-systolic pressure volume relationship (ESPVR), in any of the groups. All graphs show pre-injection (2-weeks post-MI) vs. 4-weeks post-injection values. (*p<0.05 paired t-test; graphs represent mean±SEM)