Table 1.

Cardiac MRI Global Function and Scar Size

Parameter	Group	Baseline	2 weeks (pre- injection)	4 weeks	6 weeks	Overall within group p value
LV mass (g)	ckit+ hCSC / hMSC	67.4±10.50	77.9±9.51	93.5±16.41	98.6±18.89	0.001
	ckit+ hCSC alone	64.7±8.26	82.9±8.96	92.2±11.93	100.4±18.96	0.011
	hMSC alone	68.8±8.76	80.4±7.12	91.1±7.85	103.6±5.35	0.002
	Placebo	64.5±12.14	75.9±10.72	85.0±11.13	93.8±5.44	0.019
EDV (ml)	ckit+ hCSC / hMSC	66.5±8.49	93.1±11.99	97.7±12.23	95.0±14.90	0.481
	ckit+ hCSC alone	72.9±11.88	102±18.69	101.9±18.33	109.2±21.96	0.463
	hMSC alone	78.9±10.35	93.2±15.47	94.3±17.69	105.1±23.99	0.163
	Placebo	75.4±7.81	87.8±15.55	90.1±18.54	106.1±21.17*	0.059
ESV (ml)	ckit+ hCSC / hMSC	38.7±7.35	61.2±7.98	56.8±11.95	53.0±7.91	0.141
	ckit+ hCSC alone	45.6±7/93	71.8±19.94	62.0±19.52	67.2±19.19	0.095
	hMSC alone	49.6±8.74	67.5±13.3	59.2±17.01	67.4±22.46	0.309
	Placebo	43.2±3.91	58.8±12.8	59.1±21.17	74.38±20.52*	0.102
SV (ml)	ckit+ hCSC / hMSC	27.7±3.84	31.9±7.44	40.9±6.31	42.0±9.60	<0.001
	ckit+ hCSC alone	27.3±5.72	30.3±2.54	39.8±3.22	41.9±6.84	<0.001
	hMSC alone	29.3±4.51	25.6±2.76	35.0±5.84	37.9±6.20	<0.001
	Placebo	31.6±7.93	28.18±7.34	31.0±8.59	31.7±0.72	0.369
EF (%)	ckit+ hCSC / hMSC	41.9±5.48	34.1±5.69	42.2±7.02	43.8±5.4	<0.001
	ckit+ hCSC alone	37.4±4.82	30.8±7.74	40.3±9.01	39.3±8.36	<0.001
	hMSC alone	37.5±4.81	27.8±2.76	38.0±7.86	37.1±8.32	<0.001
	Placebo	41.5±6.86	32.38±7.02	35.4±12.17	30.0±4.61	0.945
Scar mass (g)	ckit+ hCSC / hMSC	0	14.1±2.40	12.3±2.66	11.2±2.58†	<0.001
	ckit+ hCSC alone	0	14.1±3.57	13.2±2.96	12.5±2.85	0.006
	hMSC alone	0	13.8±2.74	12.0±1.77	12.4±2.51	0.015
	Placebo	0	15.1±6.95	16.1±8.02	17.2±6.83	0.430
Scar size (% LV mass)	ckit+ hCSC / hMSC	0	19.1±1.58	15.0±2.00	12.1±2.12†	<0.001
	ckit+ hCSC alone	0	17.5±3.11	14.5±2.07	13.0±1.92	<0.001
	hMSC alone	0	17.8±3.11	14.3±1.55	13.5±2.61	<0.001
	Placebo	0	19.6±7.09	18.9±6.90	18.9±6.97	0.043

Values are mean±SD. Within and between groups repeated measures ANOVA compares pre-injection (2 weeks post-MI) vs. post-injection timepoints.

^*p<0.05 within group repeated measures ANOVA at 6 weeks;

^†p<0.05 combination hCSC/hMSC vs hMSC alone and hCSC alone between group repeated measures ANOVA at 6 weeks.