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. Author manuscript; available in PMC: 2013 Feb 22.
Published in final edited form as: J Immunol. 2010 Sep 15;185(8):4609–4617. doi: 10.4049/jimmunol.1002008

FIGURE 6.

FIGURE 6

Lfng improves the competitive fitness of Lck-deficient and Ptcra-deficient DN3b thymocytes. A, DP thymocyte production in Lfng Tg+ Lck−/− + WT versus Lck−/− + WT mixed chimeras. Left panel, Relative contribution of Lfng Tg+Lck−/−, Lck−/−, and WT donor cells to the DP thymocyte pool in individual thymic lobes. Right panel, Absolute numbers of DP thymocytes derived from Lfng Tg+Lck−/− (diagonal lines), Lck−/− (dots), and WT (gray) donors in individual thymic lobes. B, DP thymocyte production in Lfng Tg+Ptcra−/− + WT versus Ptcra−/− + WT mixed chimeras. Left panel, Relative contribution of Lfng Tg+Ptcra−/−, Ptcra−/−, and WT donor cells to the DP thymocyte pool in individual thymic lobes. Right panel, Absolute numbers of DP thymocytes derived from Lfng Tg+Ptcra−/− (vertical lines), Ptcra−/− (white), and WT (gray) in individual thymic lobes. Chimeras were generated and analyzed after 3 wk as described for Fig. 2.