Figure 2.

Clinical effects of itraconazole. (A): Kaplan–Meier curves of PPFS in men receiving low-dose and high-dose itraconazole. (B): Kaplan–Meier curves of PFS in each treatment arm. (C): Waterfall plots showing best PSA responses among men receiving low-dose and high-dose itraconazole. The asterisk denotes a clipped PSA value. Prior treatment with ketoconazole is indicated by the hashed bars. (D): Waterfall plots showing best objective responses in measurable lesions according to Response Evaluation Criteria in Solid Tumors, version 1.0. Prior treatment with ketoconazole is indicated by the hashed bars (and daggers).

Abbreviations: CI, confidence interval; PFS, progression-free survival; PPFS, PSA progression-free survival; PSA, prostate-specific antigen.