Table 3.

Number of unfavorable alleles in telomere maintenance genes and all-cause or breast cancer-specific mortality after 8 years of follow-up among a population-based cohort of women diagnosed with breast cancer in 1996–1997, Long Island Breast Cancer Study Project.

No of Unfavorable alleles/genotypes*	Telomere length (T/S ratio)**	No. of cases	All-cause mortality		Breast cancer-specific mortality
			Deaths	HR (95% CI) #	Deaths	HR(95% CI) #
0–1	1.09	163	20	1.00	8	1.00
2–3	1.03	520	90	1.36 (0.84–2.21)	54	2.15 (1.02–4.51)
4–5	1.02	218	61	2.24 (1.35–3.72)	35	3.53 (1.64–7.62)

^*Carrying PINX1-33 G-allele, POT1-18 T-allele, TERF2-03 GG, TERT-14 CC, and TERT-67 TT genotypes;

^**Means

^#Adjusted for age at diagnosis as continuous, HR = 1.54 (95%CI: 1.22–1.96) for all-cause

mortality, P_trend = 0.0004; HR = 1.78 (95%CI: 1.30–2.45) for breast cancer-specific mortality, P_trend = 0.0004