Table 3.
No of Unfavorable alleles/genotypes* | Telomere length (T/S ratio)** | No. of cases | All-cause mortality | Breast cancer-specific mortality | ||
---|---|---|---|---|---|---|
| ||||||
Deaths | HR (95% CI) # | Deaths | HR(95% CI) # | |||
0–1 | 1.09 | 163 | 20 | 1.00 | 8 | 1.00 |
2–3 | 1.03 | 520 | 90 | 1.36 (0.84–2.21) | 54 | 2.15 (1.02–4.51) |
4–5 | 1.02 | 218 | 61 | 2.24 (1.35–3.72) | 35 | 3.53 (1.64–7.62) |
Carrying PINX1-33 G-allele, POT1-18 T-allele, TERF2-03 GG, TERT-14 CC, and TERT-67 TT genotypes;
Means
Adjusted for age at diagnosis as continuous, HR = 1.54 (95%CI: 1.22–1.96) for all-cause
mortality, Ptrend = 0.0004; HR = 1.78 (95%CI: 1.30–2.45) for breast cancer-specific mortality, Ptrend = 0.0004