Fig. 5.
Postsynaptic 2-AG promotes D1R+D2R enhancement of firing through CB1Rs. (A, B) Example traces (A) and time course experiments (B) showing that filling a post synaptic neuron with 2-AG allowed subthreshold doses of D1R+D2R agonists to increase firing. (C, D) Filling the postsynaptic neuron with 2-AG did not allow a D1R agonist (C, 10 µM) or D2R agonist (D, 10 µM) alone to enhance firing. (E) The 2-AG+D1R+D2R increase in firing required CB1Rs. (F) Grouped data. * P<0.05 2-AG+D1R+D2R vs. other groups.