Table 1.
Increased firing with JZL/D1/D2 was not accompanied by a change in the action potential threshold or amplitude (suggesting no changes in sodium channel function) or input resistance (suggesting no changes in ion channels such as inwardly rectifying potassium channel and potassium leak channels that are active at the resting potential). Data are taken 8 min after addition of JZL, or 8 min after addition of D1R and D2R agonists in the presence of JZL
Baseline | Post-JZL | JZL+D1R+D2R | |
---|---|---|---|
Action potential threshold (mV) | −45.54±1.53 | −45.64±1.58 | −46.35±1.87 |
Action potential amplitude (mV) | 79.43±2.13 | 79.04±2.61 | 77.85±2.94 |
Input resistance (MΩ) | 63.17±6.21 | 62.87±5.53 | 63.83±6.45 |
JZL, JZL184.
All F<1 and P>0.1.