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. Author manuscript; available in PMC: 2014 Jan 18.
Published in final edited form as: Circ Res. 2012 Nov 19;112(2):289–297. doi: 10.1161/CIRCRESAHA.111.300003

Figure 2. Total PDE and PDE3 activities are decreased in SR microsomes isolated from PDE3A−/− hearts.

Figure 2

PDE activity in WT and PDE3A−/− cardiac SR fractions, expressed as (A) specific activity (pmol cAMP hydrolyzed/min/mg) or (B) a percentage of the total PDE activity in WT hearts. Total PDE activity was determined in 3 independent SR microsomal preparations using cilostamide to inhibit PDE3, rolipram to inhibit PDE4 and IBMX to inhibit total PDE activity. *p<0.001 vs WT, **p<0.05 vs WT total PDE activity.