The PAGE study, funded in 2008, consists of a coordinating center (Rutgers University and Information Sciences Institute at the University of Southern California) and four study sites: the Causal Variants Across the Life Course (CALiCo) consortium accessing the Atherosclerosis Risk in Communities (ARIC), Coronary Artery Risk in Young Adults (CARDIA), Cardiovascular Heart Study (CHS), Strong Heart Cohort and Family Studies (SHS/SHFS), and Study of Latinos (SOL); Epidemiologic Architecture for Genes Linked to Environment (EAGLE) accessing the National Health and Nutrition Examination Surveys (NHANES) and Vanderbilt University’s biorepository linked to de-identified medical records (BioVU); the Multiethnic Cohort (MEC); and the Women’s Health Initiative (WHI).