Table 1.

SCC23 initial feed and final loading, and sizes of the Ac-DEX-SCC23 particles before and after lyophilization.

Ac-DEX Particles	Initial feeda % (w/w)	[Ag]b μg Ag per mg particle	[SCC23]c μg SCC23 per mg particle	Loading SCC23 % (w/w)	Loading efficiencyd %	Size after sonicatione (nm)	Size after lyophilizationf (nm)	Yieldg %
Ac-DEX-SCC23-1	10	11	60	6.0	60	120 ± 40	110 ± 40	95
Ac-DEX-SCC23-2	20	24	130	13.0	65	140 ± 50	120 ± 50	85
Ac-DEX-SCC23-3	30	28	154	15.4	51	120 ± 40	120 ± 50	83
Ac-DEX-SCC23-4	40	30	165	16.5	41	100 ± 40	700 ± 200	81
Ac-DEX-SCC23-5	50	32	171	17.1	34	100 ± 40	700 ± 200	84

^aAmount of SCC23 added to the Ac-DEX polymer prior to the particle formation.

^bThe concentration of silver was determined by ICP.

^cThe concentration of SCC23 was calculated taking in consideration the MW of SCC23 (585.25 g.mol⁻¹) and the MW of silver (107.87 g.mol⁻¹).

^dThe loading efficiency was calculated based on the initial feed and the final loading of SCC23.

^eSize of the Ac-DEX particles measured by DLS just after the sonication procedure (average of three measurements).

^fSize of the particles measured after centrifugation, washing, lyophilization and redispersion in PBS (average of three measurements).

^gYield was calculated based on the amount of Ac-DEX particles recovered after lyophilization.