Table 1.
Comparison of clinicopathological features according to HER-2 overexpression/amplification
| Clinicopathological features |
HER-2 overexpression/amplification |
|
|
|---|---|---|---|
| HER-2/neupositive (n = 27) | HER-2/neunegative (n = 200) | P | |
| Age |
|
|
0.151 |
| <65 years |
18 |
96 |
|
| ≥65 years |
9 |
104 |
|
| Sex |
|
|
0.765 |
| male |
18 |
139 |
|
| female |
9 |
61 |
|
| Lauren |
|
|
0.001 |
| intestinal |
26 |
118 |
|
| diffuse |
0 |
49 |
|
| mixed |
1 |
33 |
|
| WHO classification |
|
|
0.001 |
| W/D |
9 |
24 |
|
| M/D |
16 |
97 |
|
| P/D |
2 |
79 |
|
| Tumor size |
|
|
0.002 |
| ≥5 cm |
18 |
72 |
|
| <5 cm |
9 |
128 |
|
| Tumor location |
|
|
0.258 |
| cardia |
21 |
128 |
|
| corpus |
5 |
45 |
|
| antrum |
1 |
27 |
|
| Invasion depth |
|
|
0.322 |
| T1 |
1 |
19 |
|
| T2 |
4 |
32 |
|
| T3 |
22 |
149 |
|
| Lymph node |
|
|
0.022 |
| present |
20 |
118 |
|
| absent |
7 |
82 |
|
| TNM stage |
|
|
0.320 |
| I |
3 |
43 |
|
| II |
6 |
52 |
|
| III |
18 |
105 |
|
| Vessel invasion |
|
|
0.241 |
| present |
4 |
16 |
|
| absent |
23 |
184 |
|
| Borrmann |
|
|
0.133 |
| I |
4 |
26 |
|
| II |
17 |
102 |
|
| III |
6 |
64 |
|
| IV | 0 | 8 | |
M/D: moderately differentiated; P/D: poorly differentiated; W/D: well differentiated
WHO: World Health Organization.