Table 3.
Frequency distribution of all drug-related adverse events of at least grade 3
| |
Dose level |
|
||
|---|---|---|---|---|
| Event | 1 | 2 | 3 | Total |
| Number of patients |
4 (100%) |
13 (100%) |
7 (100%) |
24 (100%) |
| Nausea |
1 (25%) |
2 (15%) |
3 (43%) |
6 (25%) |
| Vomiting |
2 (50%) |
2 (15%) |
1 (14%) |
5 (21%) |
| Dehydration |
|
|
1 (14%) |
1 (4%) |
| Diarrhoea |
|
|
1 (14%) |
1 (4%) |
| Dysphagia |
|
1 (8%) |
|
1 (4%) |
| Heartburn/dyspepsia |
|
|
1 (14%) |
1 (4%) |
| Fatigue |
1 (25%) |
1 (8%) |
3 (43%) |
5 (21%) |
| Pain |
|
|
1 (14%) |
1 (4%) |
| Platelets |
|
1 (8%) |
1 (14%) |
2 (8%) |
| Leukocytes |
|
|
1 (14%) |
1 (4%) |
| Neutrophils | 1 (14%) | 1 (4%) | ||