Table 6.
Surgical results and overall response
| |
Dose level |
|
||
|---|---|---|---|---|
| 1 | 2 | 3 | Total | |
| Number of patients |
4 (100%) |
13 (100%) |
7 (100%) |
24 (100%) |
| Surgery? |
|
|
|
|
| No |
1 (25%) |
2 (15%) |
3 (43%) |
6 (25%) |
| Yes |
3 (75%) |
11 (85%) |
4 (57%) |
18 (75%) |
| If so: |
|
|
|
|
| R0 |
2 (67%) |
8 (73%) |
4 (100%) |
14 (78%) |
| Grading |
|
|
|
|
| G2 |
|
3 (27%) |
1 (25%) |
4 (22%) |
| G3 |
2 (67%) |
4 (36%) |
2 (50%) |
8 (44%) |
| Information missing |
1 (33%) |
4 (36%) |
1 (25%) |
6 (33%) |
| Response prior to surgery (RECIST) |
|
|
|
|
| N |
3 (100%) |
12 (100%) |
7 (100%) |
22 (100%) |
| PR |
2 (67%) |
3 (25%) |
2 (29%) |
7 (32%) |
| SD |
|
5 (42%) |
2 (29%) |
7 (32%) |
| PD |
1 (33%) |
2 (17%) |
2 (29%) |
1 (5%) |
| NK/ND |
|
2 (17%) |
1 (14%) |
2 (9%) |
| Staging prior to surgery (UICC) |
|
|
|
|
| N |
4 (100%) |
12 (100%) |
7 (100%) |
23 (100%) |
| II A |
|
4 (33%) |
1 (14%) |
5 (229%) |
| II B |
|
1 (8%) |
1 (14%) |
2 (9%) |
| III |
3 (75%) |
4 (33%) |
2 (29%) |
9 (39%) |
| IV |
|
|
1 (14%) |
1 (4%) |
| NK/ND |
1 (25%) |
3 (25%) |
2 (29%) |
6 (26%) |
| Pathologic response
[15] |
|
|
|
|
| N |
3 (100%) |
11 (100%) |
4 (100%) |
18 (100%) |
| CR |
|
4 (36%) |
2 (50%) |
6 (33%) |
| PR |
1 (33%) |
4 (36%) |
2 (50%) |
7 (39%) |
| SD |
|
1 (9%) |
|
1 (6%) |
| PD |
1 (33%) |
1 (9%) |
|
2 (11%) |
| NK/ND |
1 (33%) |
1 (9%) |
|
2 (11%) |
| Staging after surgery (UICC) |
|
|
|
|
| N |
3 (100%) |
11 (100%) |
4 (100%) |
18 (100%) |
| 0 |
|
2 (18%) |
1 (25%) |
3 (17%) |
| I |
|
1 (9%) |
1 (25%) |
2 (11%) |
| II A |
1 (33%) |
2 (18%) |
|
3 (17%) |
| II B |
1 (33%) |
2 (18%) |
2 (50%) |
5 (28%) |
| III |
|
1 (9%) |
|
1 (6%) |
| NK/ND | 1 (33%) | 3 (27%) | 4 (22%) | |