Table 1.
Focal ischemia models in spontaneously hypertensive
| Author | Substrains | Age | BW (g) | MABP (mmHg) | Methods of MCAO | CBF | References |
|---|---|---|---|---|---|---|---|
| Oyama N, et al. |
SHR/Charles River Jpan |
10 wk |
NA |
124±5 (SEM) |
intraluminal suture |
LDF |
J Neurosci Res 2010;88:2889-2898 |
| Zhao X, et al. |
SHR/Harlan |
NA |
NA |
NA |
dMCAO+ipsi-CCAO (Brint) |
LDF |
Stroke 2010;41:363-367 |
| Kranz A, et al. |
SHR/Charles River |
NA |
250 |
NA |
pMCAO (Tamura) |
|
Brain Res 2010;1315:128-136 |
| Yang Y, et al. |
SHR* |
NA |
300-320 |
NA |
intraluminal suture |
|
J Neurochem 2010;112:134-149 |
| Ito H, et al. |
SHR/Hos, Japan SLC |
20-24 wk |
346±33 |
209±13 |
photothrombotic dMCAO |
LDF |
J Cereb Blood Flow Metab 2010;30:343-351 |
| Sun L, et al. |
SHR/Janvier France |
NA |
300-350 |
120±11 |
blood clots embolism |
|
J Cereb Blood Flow Metab 2010;30:1651-1660 |
| Porritt MJ, et al. |
SHR/ARC Australia |
16 mo |
438±11 |
SBP=200-210 |
intraluminal suture |
|
J Cereb Blood Flow Metab 2010;30:1520-1526 |
| Yao H, et al. |
SHR/Izm, Japan SLC |
5-7 mo |
352±12 |
172±12 |
photothrombotic dMCAO/Re |
LDF |
Neurochem Res 2009;34:1999-2007 |
| Yao H, et al. |
SHR/Izm, Japan SLC |
5-7 mo |
NA |
182 (mean) |
photothrombotic dMCAO/Re |
LDF |
J Cereb Blood Flow Metab 2009;29:565-574 |
| McCabe C, et al. |
SHRSP/Gla |
12-16 wk |
220-390 |
93±4 |
intraluminal suture |
MRI |
Stroke 2009;40:3864-3868 |
| Yan Y-P, et al. |
SHR/Charles River USA |
NA |
270-320 |
NA |
intraluminal suture |
LDF |
Neurochem Int 2009;55:826-832 |
| Ashioti M, et al. |
SHR/Charles River UK |
NA |
200-250 |
NA |
dMCAO+ipsi-CCAO |
|
BMC Neurosci 2009;10:82 |
| Ishikawa E, et al. |
SHR/Kyushu |
5-8 mo |
360-440 |
154±11 |
photothrombotic dMCAO |
LDF |
J Neurol Sci 2009;285:78-84 |
| Omura-Matsuoka E, et al. |
SHR/Charles River Jpan |
10-15 wk |
250-350 |
181±10 |
intraluminal suture |
LDF |
Hypertens Res 2009;32:548-553 |
| Cao F, et al. |
SHRSP* |
13-15 wk |
250-300 |
NA |
dMCAO |
|
Brain Res 2009;1272:52-61 |
| Liu Y-P, et al. |
SHR/Charles River USA |
NA |
290-310 |
130-140 |
intraluminal suture |
LDF |
J Cereb Blood Flow Metab 2009;29:780-791 |
| Sasaki T, et al. |
SHR/Charles River Jpan |
NA |
320±40 |
NA |
dMCAO+ipsi-CCAO (Brint) |
LDF |
Neurosci Lett 2009;449:61-65 |
| Henning EC, et al. |
SHR/Charles River USA |
3-4 mo |
350±20 |
NA |
intraluminal suture |
|
J Cereb Blood Flow Metab 2009;29:1229-1239 |
| Dharap A, et al. |
SHR/Charles River USA |
NA |
280-300 |
NA |
intraluminal suture |
|
J Cereb Blood Flow Metab 2009;29:675-687 |
| Ishibashi S, et al. |
SHR/Charles River USA |
8 wk |
180-220 |
NA |
dMCAO |
|
J Cereb Blood Flow Metab 2009;29:606-620 |
| Yamashita T, et al. |
SHR/Izm, Japan SLC |
13 wk |
250-280 |
117±29 |
intraluminal suture |
LDF |
J Cereb Blood Flow Metab 2009;29:715-725 |
| Fujiwara N, et al. |
SHR/Charles River USA |
NA |
303±8 |
183±6 |
blood clots embolism |
LDF |
BMC Neurosci 2009;10:79 |
| Murata Y, et al. |
SHR/Charles River USA |
NA |
283±8 |
184±5 |
blood clots embolism |
LDF |
Stroke 2008;39:3372-3377 |
| Matsuzaki T, et al. |
SHR/Izm, Japan SLC |
9 wk |
240-290 |
126±17 |
intraluminal suture |
LDF |
Neurol Res 2008;30:531-535 |
| Kozak W, et al. |
SHR/Charles River USA |
12-13 wk |
275-300 |
135±8 (telemetry) |
intraluminal suture |
LDF |
J Pharmacol Exp Ther 2008;326:773-782 |
| Henning EC, et al. |
SHR/Charles River USA |
3-4 mo |
300-360 |
SBP=165-185 |
intraluminal suture |
|
Stroke 2008;39:3405-3410 |
| Park S-W, et al. |
SHR/Charles River USA |
NA |
250-350 |
NA |
intraluminal suture |
LDF |
J Neurosurg 2007;107:593-599 |
| Korde AS, et al. |
SHR/Harlan |
NA |
250-350 |
94±3 |
dMCAO+ipsi-CCAO (Brint) |
LDF |
J Neurotrauma 2007;24:895-908 |
| Kurasako T, et al. |
SHR/Harlan |
NA |
220-300 |
101±12 |
dMCAO+ipsi-CCAO (Brint) |
|
J Cereb Blood Flow Metab 2007;27:1919-1930 |
| Jimenez-Altayo F, et al. |
SHR/Janvier Spain |
13-15 wk |
341±4 (SEM) |
SBP=204±2 (SEM) |
intraluminal suture |
|
Am J Physiol Heart Circ Physiol 2007;293:H628-635 |
| Tureyen K, et al. |
SHR/Charles River USA |
NA |
NA |
135±9 |
intraluminal suture |
LDF |
J Neurochem 2007;101:41-56 |
| Yao H, et al. |
SHRSP/Izm, Japan SLC |
5 mo |
315±30 |
241±22 |
photothrombotic dMCAO |
LDF |
Physiol Genomics 2007;30:69-73 |
| Ashioti M, et al. |
SHR/Charles River UK |
NA |
265±9 |
NA |
dMCAO+ipsi-CCAO |
|
Brain Res 2007;1145:177-189 |
| Mariucci G, et al. |
SHR/Charles River Italy |
12-14 wk |
250-330 |
NA |
pMCAO (Tamura) |
|
Neurosci Lett 2007;415:77-80 |
| Adibhatla RM, et al. |
SHR/Charles River USA |
NA |
250-300 |
NA |
intraluminal suture |
|
Brain Res 2007;1134:199-205 |
| Leker RR, et al. |
SHR/Tel Aviv |
NA |
NA |
NA |
dMCAO |
|
Stroke 2007;38:153-161 |
| Kumai Y, et al. |
SHR/Kyushu |
5-8 mo |
340-435 |
164±2 (SEM) |
photothrombotic dMCAO |
LDF |
J Cereb Blood Flow Metab 2007;27:1152-1160 |
| Yang Y, et al. |
SHR* |
NA |
300-320 |
NA |
intraluminal suture |
|
J Cereb Blood Flow Metab 2007;27:697-709 |
| Yan Y-P, et al. |
SHR/Charles River USA |
NA |
270-300 |
NA |
intraluminal suture |
LDF |
J Cereb Blood Flow Metab 2007;27:1213-1224 |
| Takasawa M, et al. |
SHR/Charles River UK |
NA |
295-305 |
NA |
dMCAO+ipsi-CCAO |
|
J Cereb Blood Flow Metab 2007;27:679-689 |
| Akaiwa K, et al. |
SHR* |
NA |
250-290 |
144±5 |
intraluminal suture |
LDF |
Brain Res 2006;1122:47-55 |
| Yan Y-P, et al. |
SHR/Charles River USA |
NA |
250-300 |
130-140 |
intraluminal suture |
LDF |
Eur J Neurosci 2006;24:45-54 |
| Lammer A, et al. |
SHR/Charles River Germany |
NA |
250-300 |
NA |
pMCAO (Tamura) |
|
Eur J Neurosci 2006;23:2824-2828 |
| Bowen KK, et al. |
SHR/Charles River USA |
NA |
280-320 |
NA |
intraluminal suture |
LDF |
Neurochem Int 2006;49:127-135 |
| Komitova M, et al. |
SHR/Mollegaard |
6 mo |
NA |
NA |
dMCAO |
|
Exp Neurol 2006;199:113-121 |
| Zhao L, et al. |
SHR/Charles River USA |
NA |
250-350 |
118±12 |
dMCAO+ipsi-CCAO (Brint) |
AR / LDF |
J Cereb Blood Flow Metab 2006;26:1128-1140 |
| Zhang B, et al. |
SHRSP* |
16-18 wk |
NA |
204±7 |
dMCAO |
|
J Cereb Blood Flow Metab 2006;26:708-721 |
| Furuya K, et al. |
SHR/Charles River Jpan |
NA |
280-320 |
NA |
dMCAO+ipsi-CCAO (Brint) |
LDF |
J Neurosurg 2005;103:715-723 |
| Kamiya T, et al. |
SHR/Harlan |
NA |
225-325 |
161±13 |
dMCAO+ipsi-CCAO (Brint) |
AR |
Stroke 2005;36:2463-2467 |
| Naylor M, et al. |
SHR/Charles River USA |
NA |
280-320 |
NA |
intraluminal suture |
LDF |
Neurochem Int 2005;47:565-572 |
| Adibhatla RM, et al. |
SHR* |
NA |
250-275 |
NA |
intraluminal suture |
LDF |
Brain Res 2005;1058:193-197 |
| Tsuji K, et al. |
SHR* |
NA |
260-280 |
NA |
intraluminal suture |
LDF |
Stroke 2005;36:1954-1959 |
| Gunther A, et al. |
SHR/Charles River Germany |
NA |
250-330 |
NA |
pMCAO (Tamura) |
|
Eur J Neurosci 2005;21:3189-3194 |
| Vemuganti R |
SHR/Charles River USA |
NA |
280-320 |
NA |
intraluminal suture |
LDF |
Neurochem Int 2005;47:136-142 |
| Komitova M, et al. |
SHR/Mollegaard |
6 mo |
300-370 |
NA |
dMCAO |
|
Eur J Neurosci 2005;21:2397-2405 |
| Onoue S, et al. |
SHRSP* |
NA |
280-320 |
NA |
dMCAO+ipsi-CCAO (Brint) |
|
Brain Res Mol Brain Res 2005;134:189-197 |
| Hobohm C, et al. |
SHR/Charles River Germany |
NA |
250-330 |
NA |
pMCAO (Tamura) |
|
J Neurosci Res 2005;80:539-548 |
| Drummond JC, et al. |
SHR/Harlan |
16-20 wk |
375-425 |
131±9 |
intraluminal suture |
|
Anesth Analg 2005;100:841-846 |
| Ooboshi H, et al. |
SHR/Kyushu |
5-8 mo |
340-430 |
NA |
photothrombotic dMCAO |
LDF |
Circulation 2005;111:913-919 |
| Takada J, et al. |
SHR/Kyushu |
7-8 mo |
352-450 |
153±10 |
photothrombotic dMCAO |
LDF |
Gene Ther 2005;12:487-493 |
| Kumai Y, et al. |
SHR/Kyushu |
5-10 mo |
320-400 |
181±21 |
photothrombotic dMCAO |
LDF |
J Cereb Blood Flow Metab 2004;24:1359-1368 |
| Carswell HV, et al. |
SHRSP/Gla, female |
3-4 mo |
179±11 |
140±15 |
dMCAO |
|
J Cereb Blood Flow Metab 2004;24:298-304 |
| Franke H, et al. |
SHR/Charles River Germany |
NA |
250-330 |
NA |
pMCAO (Tamura) |
|
J Neuropathol Exp Neurol 2004;63:686-699 |
| Zhang B, et al. |
SHRSP* |
12-13 wk |
250-300 |
NA |
dMCAO |
|
Neuroscience 2004;126:433-440 |
| Dhodda VK, et al. |
SHR/Charles River USA |
NA |
280-320 |
NA |
intraluminal suture |
LDF |
J Neurochem 2004;89:73-89 |
| Nurmi A, et al. |
SHR/M&B A/S |
NA |
NA |
NA |
pMCAO |
|
Stroke 2004;35:987-991 |
| Vemuganti R, et al. |
SHR/Charles River USA |
NA |
280-320 |
124±11 |
intraluminal suture |
LDF |
Stroke 2004;35:179-184 |
| Ren Y, et al. |
SHR/Harlan |
NA |
250-300 |
124±16 |
dMCAO+ipsi-CCAO (Brint) |
|
J Cereb Blood Flow Metab 2004;24:42-53 |
| Kumai Y, et al. |
SHR/Kyushu, female |
5-7 mo |
195-240 |
170±2 (SEM) |
photothrombotic dMCAO |
LDF |
Exp Neurol 2003;184:904-911 |
| Babu GN, et al. |
SHR* |
NA |
250-300 |
NA |
intraluminal suture |
LDF |
Neurochem Res 2003;28:1851-1857 |
| Gautier S, et al. |
SHR/Elevage Janvier France |
NA |
270-320 |
NA |
intraluminal suture |
|
Stroke 2003;34:2975-2979 |
| Asahi M, et al. |
SHR/Taconic Farms |
NA |
NA |
NA |
blood clots embolism |
LDF |
J Cereb Blood Flow Metab 2003;23:895–899. |
| Teichner A, et al. |
SHR* |
13 wk |
NA |
NA |
dMCAO |
|
Exp Neurol 2003;182:353-360 |
| Sadanaga-Akiyoshi F, et al. |
SHR/Kyushu |
5-7 mo |
315-425 |
178±11/176±7 |
photothrombotic dMCAO |
LDF |
Neurochem Res 2003;28:1227-1234 |
| Dahlqvist P, et al. |
SHR/Mollegaard |
14-15 wk |
NA |
NA |
dMCAO |
|
Neuroscience 2003;119:643-652 |
| Pettigrew LC, et al. |
SHR/Harlan |
NA |
250-300 |
98±17 |
dMCAO+ipsi-CCAO (Brint) |
|
Neurol Res 2003;25:201-207 |
| Yan Y, et al. |
SHR/Charles River USA |
NA |
270-310 |
133±9 |
intraluminal suture |
|
Brain Res 2003;961:22-31 |
| Yamakawa H, et al. |
SHR/Taconic Farms |
12 wk |
300-500 |
SBP=156±4 |
dMCAO |
|
J Cereb Blood Flow Metab 2003;23:371-380 |
| Wiessner C, et al. |
SHR/Iffa Credo |
NA |
220-300 |
NA |
dMCAO |
|
J Cereb Blood Flow Metab 2003;23:154-165 |
| Rao VLR, et al. |
SHR/Charles River USA |
NA |
280-320 |
NA |
intraluminal suture |
LDF |
J Neurochem 2002;83:1072-1086 |
| Aoki T, et al. |
SHR* |
NA |
NA |
177±6 |
blood clots embolism |
LDF |
Stroke 2002;33:2711-2717 |
| Leker RR, et al. |
SHR/Tel Aviv |
13 wk |
NA |
127±11 |
dMCAO |
LDF |
Exp Neurol 2002;176:355-363 |
| Leker RR, et al. |
SHR/Tel Aviv |
13 wk |
NA |
127±5 |
dMCAO |
LDF |
Stroke 2002;33:1085-1092 |
| Adibhatla RM, et al. |
SHR* |
NA |
NA |
NA |
intraluminal suture |
|
Brain Res 2002;938:81-86 |
| Sakakibara Y, et al. |
SHR/Charles River USA |
NA |
280-350 |
116-128 |
intraluminal suture |
|
Brain Res 2002;931:68-73 |
| Sumii T, et al. |
SHR/Taconic Farms |
NA |
NA |
185±6 (SEM) |
blood clots embolism |
LDF |
Stroke 2002;33:831-836 |
| Jin J, et al. |
SHR/Hos, Japan SLC |
NA |
130-160 |
NA |
pMCAO |
AR |
Pharmacology 2002;64:119-125 |
| Higuchi T, et al. |
SHR/Charles River Jpan |
NA |
261±32 |
88±12 |
dMCAO+ipsi-CCAO (Brint) |
LDF |
J Cereb Blood Flow Metab 2002;22:71-79 |
| Ito T, et al. |
SHR/Taconic Farms |
8 wk |
190-240 |
SBP=153±6 (SEM) |
dMCAO |
|
Stroke 2002;33:2297-2303 |
| Wallace JA, et al. |
SHR* |
NA |
280-320 |
NA |
intraluminal suture |
|
J Cereb Blood Flow Metab 2002;22:1303-1310 |
| Komitova M, et al. |
SHR/Mollegaard |
NA |
NA |
NA |
dMCAO |
|
J Cereb Blood Flow Metab 2002;22:852-860 |
| Johanson BB, et al. |
SHR/Mollegaard |
3 mo |
NA |
NA |
dMCAO |
|
J Cereb Blood Flow Metab 2002;22:89-96 |
| Dijkhuizen RM, et al. |
SHR/Taconic Farms |
NA |
300-350 |
NA |
blood clots embolism |
MRI |
Stroke 2002;33:2100-2104 |
| Yao H, et al. |
SHR/Kyushu |
5-7 mo |
346-444 |
196 (mean) |
photothrombotic dMCAO/Re |
LDF |
Neuroreport 2002;13:1005-1008 |
| Kitayama J, et al. |
SHR/Kyushu |
5-8 mo |
305-438 |
161±5 (SEM) |
photothrombotic dMCAO |
LDF |
Brain Res 2001;922:223-228 |
| Furuya K, et al. |
SHR* |
NA |
NA |
NA |
dMCAO+ipsi-CCAO (Brint) |
|
Stroke 2001;32:2665-2674 |
| Takagi K, et al. |
SHR/Funabashi Farm Japan |
15-16 wk |
280-340 |
177±11 |
pMCAO (Tamura) |
LDF |
Neurol Res 2001;23:662-668 |
| Cole DJ, et al. |
SHR* |
16-20 wk |
375-425 |
126±9 / 131±7 |
intraluminal suture |
|
Can J Anaesth 2001;48:807-814 |
| Yan Y, et al. |
SHR/Charles River USA |
NA |
270-300 |
133±8 |
intraluminal suture |
|
J Cereb Blood Flow Metab 2001;21:711-721 |
| Rao VLR, et al. |
SHR/Charles River USA |
NA |
250-300 |
116±11 |
intraluminal suture |
LDF |
J Cereb Blood Flow Metab 2001;21:945-954 |
| Zhao Z, et al. |
SHR/Charles River Canada |
NA |
200-250 |
127±14 |
dMCAO+ipsi-CCAO |
LDF |
Brain Res 2001;909:46-50 |
| Marks L, et al. |
SHRSP/Gla |
3-5 mo |
262±11 (SEM) |
123±9 (SEM) |
dMCAO |
|
Hypertension 2001;38:116-122 |
| Gregersen R, et al. |
SHR/Mollegaard |
NA |
300-335 |
NA |
pMCAO |
|
Exp Brain Res 2001;138:384-392 |
| Yao H, et al. |
SHR/Kyushu |
5-7 mo |
350-438 |
187 (mean) |
photothrombotic dMCAO |
LDF |
Brain Res Mol Brain Res 2001;91:112-118 |
| Tejima E, et al. |
SHR* |
NA |
250-300 |
122±3 (SEM) |
blood clots embolism |
LDF |
Stroke 2001;32:1336-1340 |
| Lavie G, et al. |
SHR/Tel Aviv |
13 wk |
NA |
127±11 |
dMCAO |
|
Brain Res 2001;901:195-201 |
| Furuya K, et al. |
SHR/Charles River USA |
13-16 wk |
NA |
140±7 |
pMCAO (Tamura) |
|
J Cereb Blood Flow Metab 2001;21:226-232 |
| Holtz ML, et al. |
SHR/Harlan |
NA |
250-350 |
108±15 |
dMCAO+ipsi-CCAO (Brint) |
|
Brain Res 2001;898:49-60 |
| Fredduzzi S, et al. |
SHR/Charles River Italy |
12-14 wk |
250-330 |
NA |
pMCAO (Tamura) |
|
Neurosci Lett 2001;302:121-124 |
| Rao VLR, et al. |
SHR/Charles River USA |
NA |
250-300 |
NA |
intraluminal suture |
LDF |
J Neurosci 2001;21:1876-1883 |
| Negrin CD, et al. |
SHRSP/Gla |
13 wk |
NA |
SBP=186±6 (SEM) |
dMCAO |
|
Hypertension 2001;37:391-397 |
| Babu GN, et al. |
SHR* |
NA |
250-300 |
NA |
intraluminal suture |
LDF |
Neurosci Lett 2001;300:17-20 |
| Legos JJ, et al. |
SHR/Taconic Farms |
NA |
300-350 |
NA |
dMCAO |
|
Brain Res 2001;892:70-77 |
| Slivka AP, et al. |
SHR* |
NA |
240-400 |
NA |
dMCAO+ipsi-CCAO (Brint) |
|
Exp Neurol 2001;167:166-172 |
| Barone FC, et al. |
SHR/Taconic Farms |
NA |
290-340 |
141±3 (SEM) |
dMCAO |
|
J Pharmacol Exp Ther 2001;296:312-321 |
| Relton JK, et al. |
SHR/Taconic Farms |
NA |
250-350 |
168±15 (SEM) |
intraluminal suture |
|
Stroke 2001;32:199-205 |
| Ooboshi H, et al. |
SHR/Kyushu |
5-7 mo |
340-430 |
167±6 (SEM) |
photothrombotic dMCAO |
LDF |
Stroke 2001;32:1043-1047 |
| Dijkhuizen RM, et al. | SHR/Taconic Farms | NA | 300-350 | NA | blood clots embolism | LDF / MRI | J Cereb Blood Flow Metab 2001;21:964-971 |
*substrain unknown; NA, not available. Values are mean ± S.D. BW, body weight; MABP, mean arterial blood pressure;
MCAO, middle cerebral artery occlusion; d, distal; p, proximal; ipsi, ispsilateral; Re, reperfusion;
CBF, cerebral blood flow; LDF, laser Doppler flowmetry; AR, autoradiography; MIR, magnetic resonance imaging.