Table 3.
MGMT group-specific methylation levelsfor each CpG andthe mean methylation overthe ten CpGs
| Health group | CpG 1 | CpG 2 | CpG 3 | CpG 4 | CpG 5 | CpG 6 | CpG 7 | CpG 8 | CpG 9 | CpG 10 | Mean | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NIDDM2 |
|
0,224 |
0,565 |
0,272 |
0,232 |
0,413 |
0,436 |
0,106 |
0,373* |
0,103 |
0,853 |
0,420 |
| |
SE |
0,163 |
0,270 |
0,127 |
0,165 |
0,191 |
0,173 |
0,139 |
0,155 |
0,142 |
0,426 |
0,192 |
| |
P |
0,210 |
0,075 |
0,070 |
0,202 |
0,067 |
0,039 |
0,468 |
0,047 |
0,492 |
0,086 |
0,065 |
| IFG |
|
0,226 |
0,386 |
0,086 |
0,183 |
0,493 |
0,422 |
0,129 |
−1,599 |
0,168 |
0,856 |
0,204 |
| |
SE |
0,143 |
0,310 |
0,088 |
0,125 |
0,224 |
0,214 |
0,158 |
1,840 |
0,255 |
0,310 |
0,146 |
| |
P |
0,188 |
0,281 |
0,384 |
0,218 |
0,092 |
0,120 |
0,461 |
0,434 |
0,546 |
0,051 |
0,233 |
| pooled |
|
0,225 |
0,496* |
0,200* |
0,213 |
0,443* |
0,431* |
0,115 |
−0,386 |
0,128 |
0,854* |
0,337* |
| |
SE |
0,110 |
0,198 |
0,087 |
0,109 |
0,140 |
0,129 |
0,101 |
0,721 |
0,125 |
0,279 |
0,130 |
| P | 0,063 | 0,027 | 0,039 | 0,073 | 0,008 | 0,006 | 0,275 | 0,602 | 0,327 | 0,010 | 0,023 | |
Paired t-test of methylation changes between baseline (T0) and 8 weeks (T1). CpG numbers 2, 3, 5, 6, and 10 and the mean methylation were significantly higher methylated in the intervention groups (pooled). Asterisks indicate significances at P < 0.05. NIDDM2, patients with non-insulin-dependent diabetes mellitus type 2; IFG, patients with impaired fasting glucose; LC, lean control group; SE, standard error of the mean.