Table 1.
Baseline variables
| Total (n = 1613) | Alive (n = 1534) | Death (n = 79) | p value | |
|---|---|---|---|---|
| Age, years | 60 ± 13 | 60 ± 13 | 69 ± 13 | <0.0001 |
| Men | 919 (57%) | 874 (57%) | 45 (57%) | 0.9 |
| Prior CAD | 295 (18%) | 272 (18%) | 23 (29%) | 0.01 |
| Previous MI | 146 (9%) | 133 (9%) | 13 (16%) | 0.02 |
| Body mass index, kg/m2 | 29 ± 8 | 29 ± 8 | 29 ± 11 | 0.8 |
| CAD risk factors | ||||
| Hypertension | 1009 (63%) | 945 (62%) | 64 (81%) | 0.001 |
| Diabetes | 347 (22%) | 323 (21%) | 24 (30%) | 0.04 |
| Hypercholesterolemia | 945 (59%) | 901 (59%) | 44 (56%) | 0.6 |
| Family history | 254 (16%) | 247 (16%) | 7 (9%) | 0.09 |
| Smoking | 117 (7%) | 111 (7%) | 6 (8%) | 0.9 |
| Symptom class | ||||
| Asymptomatic | 496 (31%) | 463 (30%) | 33 (42%) | 0.03 |
| Nonanginal pain | 67 (4%) | 61 (4%) | 6 (8%) | 0.1 |
| Atypical angina | 809 (50%) | 786 (51%) | 23 (29%) | <0.001 |
| Typical angina | 47 (3%) | 45 (3%) | 2 (3%) | 0.8 |
| Shortness of breath | 194 (12%) | 179 (12%) | 15 (19%) | 0.05 |
| Type of stress | ||||
| Adenosine stress | 793 (49%) | 722 (47%) | 71 (90%) | <0.001 |
| Isotope type | ||||
| Rest/stress MIBI | 1009 (62%) | 963 (63%) | 46 (58%) | 0.4 |
| Stress Tl/rest MIBI | 544 (34%) | 512 (33%) | 32 (41%) | 0.2 |
| Rest TL/stress MIBI | 60 (4%) | 59 (4%) | 1 (1%) | 0.2 |
| sTPD, % | 3.4 ± 5.7 | 3.3 ± 5.7 | 5.3 ± 5.8 | 0.003 |
| SSS%myo, % | 2.0 ± 5.6 | 1.9 ± 5.5 | 4.4 ± 6.6 | <0.001 |
| iTPD, % | 1.8 ± 2.7 | 1.8 ± 2.6 | 3.0 ± 3.0 | <0.001 |
| SDS%myo, % | 1.0 ± 2.5 | 0.9 ± 2.4 | 2.4 ± 3.6 | <0.001 |
| stress LVEF, % | 62 ± 12 | 63 ± 12 | 58 ± 13 | <0.001 |
| rest LVEF, % | 61 ± 14 | 61 ± 13 | 59 ± 15 | 0.003 |
CAD, coronary artery disease; MI, myocardial infarction; MIBI, 99mTc-sestamibi; TL, 201Tl; sTPD, stress total perfusion deficit; SSS%myo, percentage of abnormal myocardium at stress; iTPD, ischemic total perfusion deficit; SDS%myo, percentage of ischemic myocardium; LVEF, left ventricular ejection fraction