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. 2013 Feb 22;8(2):e56328. doi: 10.1371/journal.pone.0056328

Figure 5. Association of specific vascular architecture with IDH1 status and young age.

Figure 5

(A) Example of glomeruloid appearance of tumour vessels (arrows). Haematoxylin and eosin. (B) Tumour cell positivity for mutant IDH1 associated with glomeruloid vessels. RMH5984. (C) Contrast-enhanced T1-weighted images of patient RMH5984, showing an incompletely enhancing lesion (arrow). (D) Tumour vessels forming arcade-like structures (arrows). Haematoxylin and eosin. (E) All tumours with arcade-like vascular structures were negative for IDH1 mutation by immunohistochemistry (and direct sequencing). RMH6642. (F) Contrast-enhanced T1-weighted images of patient RMH6642, with pronounced ring-like enhancement (arrow). All histopathological images original magnification×200.